Structural and functional features of factor XI
نویسندگان
چکیده
منابع مشابه
Tissue-specific expression of functional platelet factor XI is independent of plasma factor XI expression.
Platelet factor XI is an alternatively spliced product of the factor XI gene expressed specifically within megakaryocytes and platelets as an approximately 1.9-kb mRNA transcript (compared with approximately 2.1 kb in liver cells) lacking exon V. Flow cytometry with an affinity-purified factor XI antibody, with PAC1 antibody (to the GPIIb/IIIa complex on activated platelets), and with S12 antib...
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A relatively potent antiserum against highly purified, unactivated human factor XI antigen was raised in a rabbit. This antiserum, after concentration, neutralized 50% of the factor XI clotting activity of a standard normal plasma at an antiserum dilution of 1/900. The antiserum was used in a neutralization-inhibition assay to study the relation between factor XI clotting activity and factor XI...
متن کاملHuman platelets and factor XI. Localization in platelet membranes of factor XI-like activity and its functional distinction from plasma factor XI.
Because human platelets participate in the contact phase of intrinsic coagulation and contain a Factor XI-like coagulant activity, the nature of the Factor XI-like activity was examined and compared with purified plasma Factor XI. The platelet factor XI-like activity was sedimented with the particulate fraction of a platelet lysate, was inactivated by heat (t(1/2) 3.5 min, 56 degrees C), was no...
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15 صفحه اولFactor XI: purification from porcine plasma by affinity chromatography and some properties of factor XI and activated factor XI.
Porcine factor XI and activated factor XI were purified by the introduction of affinity chromatography on high molecular mass kininogen. On the affinity chromatography, it was observed that high affinity exists between porcine factor XI and high molecular mass kininogen. In the preparation, however, factor XII, plasma prekallikrein and high molecular mass kininogen were not detected. The factor...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2009
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2009.03414.x